Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T35332 |
THZ1 2HCl
THZ1二盐酸盐,THZ1 2HCl,THZ1 Dihydrochloride |
CDK | Cell Cycle/Checkpoint |
THZ1 2HCl (THZ1 Dihydrochloride) 是一种选择性、共价和变构的 CDK7 抑制剂,IC50 为 3.2 nM。 THZ1 2HCl 对多种癌细胞系具有抗增殖作用。 | |||
T3664 |
THZ1
CDK7 inhibitor,THZ1 2HCl |
CDK | Cell Cycle/Checkpoint |
THZ1 (CDK7 inhibitor) 是一种新型的选择性强效共价 CDK7 抑制剂。它还抑制CDK12和CDK13,并下调 MYC 表达。 | |||
T7296 |
THZ2
CDK7-IN-1 |
CDK | Cell Cycle/Checkpoint |
THZ2 (CDK7-IN-1) 是 THZ1 的类似物,是一种有效的选择性 CDK7 抑制剂 ,IC50值为 13.9 nM。它有治疗三阴性乳腺癌的潜力。 | |||
T39459 |
THZ-P1-2
THZ-P1-2 |
||
THZ-P1-2 is a novel, specific inhibitor of PI5P4K that effectively targets PI5P4Kα. With an IC 50 of 190 nM, THZ-P1-2 selectively inhibits PI5P4Kα by forming covalent bonds with cysteine residues located on a disordered loop present in PI5P4Kα/β/γ. This mechanism not only disrupts autophagy but also elevates TFEB signaling. Moreover, THZ-P1-2 exhibits potent anticancer effects in leukemia cell lines, making it a promising candidate for therapeutic applications. | |||
T23458 |
THZ1 Hydrochloride (1604810-83-4 free base)
THZ1 Hydrochloride |
Others | Others |
THZ1 is a covalent inhibitor of CDK7 (IC50: 3.2nM). | |||
T10546 |
bio-THZ1
|
CDK | Cell Cycle/Checkpoint |
bio-THZ1 is a biotinylated version of THZ1. THZ1 is a selective and irreversibly covalent CDK7 inhibitor (IC50: 3.2 nM). | |||
T13153 |
THZ1-R
|
CDK | Cell Cycle/Checkpoint |
THZ1-R displays diminished activity for CDK7 inhibition(Kd:142 nM). | |||
T72512 |
THZ1 Hydrochloride
|
||
THZ1 Hydrochloride,一种有效、选择性的共价CDK7抑制剂,IC50值为3.2 nM。它同样针对相关激酶CDK12和CDK13具有抑制作用,并能下调MYC表达。 |